SERPINI1

Across TCGA patient cohorts, SERPINI1 protein abundance is significantly associated with the RNA expression of many other genes, with 6,537 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SERPINI1-associated genes across cancer lineages are EIF2AK3, ANKRD36BP2, and XBP1. Each is linked with SERPINI1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SERPINI1-to-partner and partner-to-SERPINI1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SERPINI1 versus EIF2AK3 in HNSC, with a Pearson correlation of 0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINI1→partner) and Y-score (partner→SERPINI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	EIF2AK3 →	+0.410	+0.720	.001	<.001	3	4
HNSC	ANKRD36BP2 →	+1.508	+0.573	<.001	.004	3	4
BRCA	XBP1 →	+1.095	+0.496	<.001	<.001	3	3
GBM	ENPP5 →	+1.305	+0.490	<.001	.005	3	3
BRCA	ELAPOR1 →	+1.133	+0.526	.005	.009	3	3
HNSC	ADORA2B →	-0.785	-0.819	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,537 associations by consensus.

SERPINI1 vs EIF2AK3 — HNSC

Explore this scatter interactively →