SERPINI1

Across TCGA cell cohorts, SERPINI1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,765 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SERPINI1-associated GO terms across cancer lineages are ERAD pathway, Post-translational protein targeting to membrane, translocation, and Endoplasmic reticulum unfolded protein response. Each is linked with SERPINI1 in more than 10 cancer types. Because this analysis shows association rather than direction, both SERPINI1-to-partner and partner-to-SERPINI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERAD pathway grouped by SERPINI1-low versus SERPINI1-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINI1→partner) and Y-score (partner→SERPINI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ERAD pathway →	+0.055	+1.213	<.001	.001	3	11
PANCREAS	Post-translational protein targeting to membrane, translocation →	+0.068	+1.174	.005	.001	3	10
CNS	Endoplasmic reticulum unfolded protein response →	+0.062	+1.080	.003	.005	2	10
KIDNEY	Endosomal lumen acidification →	+0.134	+1.132	.001	.001	3	8
BLOOD_Lymphoma	Cellular response to unfolded protein →	+0.060	+1.059	<.001	<.001	3	8
BLOOD_Lymphoma	Response to topologically incorrect protein →	+0.066	+1.086	<.001	.003	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,765 associations by consensus.

ERAD pathway by SERPINI1 expression — BLOOD_Lymphoma

Explore this box plot interactively →