SERPINI1

Across TCGA cell cohorts, SERPINI1 mutation is significantly associated with the drug of many other genes, with 33 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SERPINI1-associated genes across cancer lineages are Oxaliplatin, Fulvestrant, and AZD5438. Each is linked with SERPINI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERPINI1-to-partner and partner-to-SERPINI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Oxaliplatin grouped by SERPINI1-low versus SERPINI1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINI1→partner) and Y-score (partner→SERPINI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Oxaliplatin →	+0.577	+2.649	.029	.046	3	2
LARGE_INTESTINE	Fulvestrant →	+0.355	+2.649	.031	.046	3	1
LARGE_INTESTINE	AZD5438 →	+0.503	+2.777	.041	.038	3	1
LARGE_INTESTINE	SGC-CBP30 →	+0.347	+2.649	.013	.046	3	1
LARGE_INTESTINE	CZC24832 →	+0.292	+2.646	.024	.047	3	1
LARGE_INTESTINE	CDK9_5576 →	+0.578	+2.649	.026	.046	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Oxaliplatin by SERPINI1 expression — LARGE_INTESTINE

Explore this box plot interactively →