SERPINH1

Across TCGA patient cohorts, SERPINH1 mutation is significantly associated with the immune_cell of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERPINH1-associated genes across cancer lineages are GMP, CMP, and mv Endothelial cells. Each is linked with SERPINH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERPINH1-to-partner and partner-to-SERPINH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GMP grouped by SERPINH1-low versus SERPINH1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINH1→partner) and Y-score (partner→SERPINH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	GMP →	+0.092	+4.543	<.001	<.001	3	2
SKCM	CMP →	+0.053	+2.987	.015	.034	3	1
UCEC	mv Endothelial cells →	-0.020	-3.117	.032	.019	3	1
UCEC	Myocytes →	+0.033	+2.246	.012	.030	3	1
UCEC	Basophils →	+0.177	+2.415	.009	.003	3	1
UCEC	pDC →	+0.042	+2.491	.029	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

GMP by SERPINH1 expression — SKCM

Explore this box plot interactively →