SERPINH1

Across TCGA cell cohorts, SERPINH1 mutation is significantly associated with the RNA expression of many other genes, with 560 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SERPINH1-associated genes across cancer lineages are OPCML, KRTAP4-9, and CLDN34. Each is linked with SERPINH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERPINH1-to-partner and partner-to-SERPINH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OPCML grouped by SERPINH1-low versus SERPINH1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINH1→partner) and Y-score (partner→SERPINH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OPCML →	+0.141	+4.152	<.001	.009	3	1
BLOOD_Leukemia	KRTAP4-9 →	+0.052	+5.786	<.001	<.001	3	1
BLOOD_Leukemia	CLDN34 →	+0.067	+5.569	<.001	.001	3	1
STOMACH	CT47A6 →	+0.046	+5.285	<.001	.003	3	1
LARGE_INTESTINE	POLDIP3 →	+0.608	+3.212	.003	.006	3	1
LARGE_INTESTINE	MCAT →	+0.764	+3.212	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 560 associations by consensus.

OPCML by SERPINH1 expression — BLOOD_Leukemia

Explore this box plot interactively →