SERPINF2

Across TCGA pan-cancer cohorts, SERPINF2 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated SERPINF2 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SERPINF2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SERPINF2 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

LUAD, CCRCC, and UCEC are the cancer types where SERPINF2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.209	0.740	<.001	44	view →
CCRCC	DFS	Median	All	0.889	0.616	.002	32	view →
UCEC	OS	Median	III,IV	0.507	1.000	.022	12	view →
GBM	OS	Tertile	All	0.228	0.557	.010	8	view →
LSCC	DFS	Median	II,III,IV	0.827	1.000	.003	7	view →
COAD	DFS	Median	IV	0.493	0.944	.031	6	view →
PDAC	OS	Median	IV	0.836	0.491	.024	3	view →
HNSC	DFS	Tertile	III,IV	1.000	0.919	.038	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

SERPINF2–LUAD (OS)

Open the LUAD breakdown →