SERPINF2

Across TCGA patient cohorts, SERPINF2 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERPINF2-associated genes across cancer lineages are N-Ras, SCD, and INPP4B. Each is linked with SERPINF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERPINF2-to-partner and partner-to-SERPINF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, N-Ras grouped by SERPINF2-low versus SERPINF2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINF2→partner) and Y-score (partner→SERPINF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	N-Ras →	+0.140	+3.321	.049	.010	3	2
SKCM	SCD →	+0.173	+2.857	.023	.032	3	1
UCEC	INPP4B →	-0.464	-3.000	.008	.036	3	1
UCEC	Caspase-8 →	-0.364	-2.973	.008	.035	3	1
UCEC	CD49b →	-0.393	-3.156	.011	.020	3	1
UCEC	Tuberin →	+0.433	+3.169	.003	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

N-Ras by SERPINF2 expression — SKCM

Explore this box plot interactively →