SERPIND1

Across TCGA pan-cancer cohorts, SERPIND1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SERPIND1 data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SERPIND1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SERPIND1 expression acts as an unfavorable survival marker, although some lineages such as GBM and CCRCC show a favorable association.

LUAD, GBM, and LSCC are the cancer types where SERPIND1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	II,III,IV	0.310	0.851	.004	31	view →
GBM	DFS	Median	All	0.522	0.249	.003	15	view →
LSCC	DFS	Median	II,III,IV	0.840	1.000	.007	13	view →
CCRCC	OS	Median	IV	1.000	0.451	.016	7	view →
COAD	DFS	Median	IV	0.493	0.944	.031	6	view →
HNSC	OS	Median	II,III,IV	0.952	1.000	.016	3	view →
PDAC	OS	Median	IV	0.836	0.491	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SERPIND1–LUAD (OS)

Open the LUAD breakdown →