SERPIND1

Across TCGA patient cohorts, SERPIND1 mutation is significantly associated with the RNA expression of many other genes, with 1,374 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERPIND1-associated genes across cancer lineages are OR5M4P, NSA2P4, and TTTY18. Each is linked with SERPIND1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERPIND1-to-partner and partner-to-SERPIND1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5M4P grouped by SERPIND1-low versus SERPIND1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPIND1→partner) and Y-score (partner→SERPIND1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	OR5M4P →	+0.054	+7.133	<.001	<.001	3	2
BLCA	NSA2P4 →	+0.088	+3.715	.004	.006	3	2
HNSC	TTTY18 →	+0.338	+5.015	.003	.009	3	2
UCEC	GNPDA1 →	+0.352	+2.016	.004	.005	3	2
UCEC	RRP9 →	+0.353	+2.374	.004	.002	3	2
UCEC	EXOSC8 →	+0.473	+1.858	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,374 associations by consensus.

OR5M4P by SERPIND1 expression — BRCA

Explore this box plot interactively →