SERPIND1

Across TCGA patient cohorts, SERPIND1 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERPIND1-associated genes across cancer lineages are Caspase-7-cleavedD198, FoxM1, and ACVRL1. Each is linked with SERPIND1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERPIND1-to-partner and partner-to-SERPIND1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by SERPIND1-low versus SERPIND1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPIND1→partner) and Y-score (partner→SERPIND1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.828	+1.604	<.001	.021	3	2
UCEC	FoxM1 →	+0.197	+2.710	.034	.003	3	1
UCEC	ACVRL1 →	-0.129	-2.308	.008	.033	3	1
UCEC	p27_pT157 →	-0.043	-1.584	.039	.019	3	1
UCEC	PCNA →	+0.234	+2.321	.002	.001	3	1
UCEC	Rad50 →	-0.232	-3.446	.007	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Caspase-7-cleavedD198 by SERPIND1 expression — UCEC

Explore this box plot interactively →