SERPIND1

Across TCGA cell cohorts, SERPIND1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,371 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SERPIND1-associated GO terms across cancer lineages are Behavioral response to pain, Negative regulation of RNA splicing, and Negative regulation of mRNA splicing, via spliceosome. Each is linked with SERPIND1 in more than 5 cancer types. Because this analysis shows association rather than direction, both SERPIND1-to-partner and partner-to-SERPIND1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Behavioral response to pain grouped by SERPIND1-low versus SERPIND1-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPIND1→partner) and Y-score (partner→SERPIND1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Behavioral response to pain →	+0.131	+1.094	<.001	<.001	3	6
BLOOD_Myeloma	Negative regulation of RNA splicing →	+0.070	+0.060	<.001	<.001	3	5
SKIN	Negative regulation of mRNA splicing, via spliceosome →	+0.094	+1.138	<.001	.003	3	5
SOFT_TISSUE	Positive regulation of matrix metallopeptidase secretion →	-0.207	-0.397	<.001	.008	3	5
SOFT_TISSUE	Positive regulation of intracellular transport →	+0.043	+0.311	<.001	.006	3	5
SOFT_TISSUE	Positive regulation of transmission of nerve impulse →	+0.953	+0.332	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,371 associations by consensus.

Behavioral response to pain by SERPIND1 expression — SKIN

Explore this box plot interactively →