SERPINB8

Across TCGA pan-cancer cohorts, SERPINB8 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated SERPINB8 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher SERPINB8 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SERPINB8 expression acts as an unfavorable survival marker, although some lineages such as LSCC and UCEC show a favorable association.

COAD, CCRCC, and GBM are the cancer types where SERPINB8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	II,III,IV	0.863	1.000	.030	30	view →
CCRCC	DFS	Median	III,IV	0.105	0.928	.003	25	view →
GBM	DFS	Median	All	0.608	0.880	<.001	21	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	10	view →
LSCC	DFS	Median	III,IV	0.910	0.442	.013	9	view →
UCEC	OS	Tertile	All	1.000	0.844	.016	8	view →
HNSC	OS	Median	III,IV	1.000	0.484	.038	5	view →
LUAD	DFS	Quartile	II,III,IV	0.752	0.928	.016	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

SERPINB8–COAD (DFS)

Open the COAD breakdown →