SERPINB8

Across TCGA patient cohorts, SERPINB8 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERPINB8-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and eIF4E. Each is linked with SERPINB8 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERPINB8-to-partner and partner-to-SERPINB8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by SERPINB8-low versus SERPINB8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINB8→partner) and Y-score (partner→SERPINB8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.493	+1.604	.010	.021	3	2
UCEC	EGFR_pY1068 →	-0.170	-1.222	.036	.035	3	1
UCEC	eIF4E →	+0.184	+3.598	.007	.001	3	1
UCEC	ERK2 →	+0.192	+1.459	.002	.012	3	1
UCEC	GAPDH →	+0.475	+1.847	.006	.007	3	1
UCEC	ACC1 →	+0.317	+1.716	.007	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Caspase-7-cleavedD198 by SERPINB8 expression — UCEC

Explore this box plot interactively →