SERPINB7

Across TCGA pan-cancer cohorts, SERPINB7 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SERPINB7 data layer compared with 19 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SERPINB7 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SERPINB7 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

UCEC, HNSC, and LUAD are the cancer types where SERPINB7 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.833	0.969	.003	14	view →
HNSC	OS	Median	All	1.000	0.449	.023	12	view →
LUAD	DFS	Quartile	III,IV	0.944	0.373	.006	6	view →
LSCC	DFS	Median	II,III,IV	0.544	0.801	.013	6	view →
PDAC	DFS	Median	III,IV	0.886	0.508	.048	2	view →
GBM	DFS	Median	All	0.662	0.859	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SERPINB7–UCEC (DFS)

Open the UCEC breakdown →