SERPINB7

Across TCGA patient cohorts, SERPINB7 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERPINB7-associated genes across cancer lineages are TFRC, Caspase-7-cleavedD198, and ERK2. Each is linked with SERPINB7 in more than 2 cancer types. Because this analysis shows association rather than direction, both SERPINB7-to-partner and partner-to-SERPINB7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by SERPINB7-low versus SERPINB7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINB7→partner) and Y-score (partner→SERPINB7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.493	+2.999	.024	.035	3	3
UCEC	Caspase-7-cleavedD198 →	+0.708	+2.604	.003	.005	3	3
UCEC	ERK2 →	+0.195	+3.321	.014	.009	3	2
UCEC	PCNA →	+0.238	+3.584	.007	.002	3	2
UCEC	STAT3_pY705 →	-0.291	-2.105	.007	.017	3	2
UCEC	Caspase-8 →	-0.299	-3.558	.003	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

TFRC by SERPINB7 expression — UCEC

Explore this box plot interactively →