SERPINB6

Across TCGA pan-cancer cohorts, SERPINB6 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SERPINB6 data layer compared with 27 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SERPINB6 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SERPINB6 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and UCEC show a favorable association.

LSCC, LUAD, and CCRCC are the cancer types where SERPINB6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	III,IV	0.460	0.894	.009	15	view →
LUAD	OS	Quartile	II,III,IV	0.347	1.000	.003	14	view →
CCRCC	DFS	Tertile	III,IV	0.762	0.364	.009	12	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	9	view →
HNSC	DFS	Median	II,III,IV	0.906	0.965	.035	2	view →
UCEC	DFS	Quartile	All	0.958	0.833	.047	2	view →
GBM	OS	Quartile	All	0.402	0.631	.024	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SERPINB6–LSCC (DFS)

Open the LSCC breakdown →