SERPINB6

Across TCGA patient cohorts, SERPINB6 mutation is significantly associated with the RNA expression of many other genes, with 2,466 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERPINB6-associated genes across cancer lineages are NPBWR2, RN7SKP158, and RPS21P2. Each is linked with SERPINB6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERPINB6-to-partner and partner-to-SERPINB6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPBWR2 grouped by SERPINB6-low versus SERPINB6-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINB6→partner) and Y-score (partner→SERPINB6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	NPBWR2 →	+0.056	+5.010	<.001	.009	3	2
HNSC	RN7SKP158 →	+0.095	+3.952	.009	.005	3	2
HNSC	RPS21P2 →	+0.123	+4.141	.007	.003	3	2
HNSC	MIR3927 →	+0.290	+5.351	.001	.002	3	2
BRCA	WBP1LP3 →	+0.178	+7.731	<.001	.009	3	2
STAD	MIR4276 →	+0.568	+5.366	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,466 associations by consensus.

NPBWR2 by SERPINB6 expression — CESC

Explore this box plot interactively →