SERPINB6

Across TCGA patient cohorts, SERPINB6 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERPINB6-associated genes across cancer lineages are Shc_pY317, FASN, and FoxM1. Each is linked with SERPINB6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERPINB6-to-partner and partner-to-SERPINB6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by SERPINB6-low versus SERPINB6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINB6→partner) and Y-score (partner→SERPINB6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.140	-1.584	.018	.036	3	2
UCEC	FASN →	+0.382	+2.000	.013	.030	3	1
UCEC	FoxM1 →	+0.242	+2.179	.017	.034	3	1
UCEC	JNK2 →	+0.175	+3.196	.025	.009	3	1
UCEC	MSH2 →	-0.295	-1.990	.001	.030	3	1
UCEC	Myosin-IIa →	+0.158	+1.814	.039	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Shc_pY317 by SERPINB6 expression — UCEC

Explore this box plot interactively →