Across TCGA patient cohorts, SERPINB5 protein abundance is significantly associated with the RNA expression of many other genes, with 16,140 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible SERPINB5-associated genes across cancer lineages are DSC2, SERPINB8, and KRT16. Each is linked with SERPINB5 in more than 6 cancer types. Because this analysis shows association rather than direction, both SERPINB5-to-partner and partner-to-SERPINB5 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINB5→partner) and Y-score (partner→SERPINB5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DSC2 →	+1.409	+1.049	<.001	<.001	3	7
UCEC	SERPINB8 →	+0.728	+1.559	<.001	<.001	3	7
BRCA	KRT16 →	+2.683	+1.452	<.001	<.001	3	7
UCEC	GJB3 →	+1.287	+1.437	<.001	<.001	3	7
LSCC	KRT6A →	+2.816	+1.201	<.001	<.001	3	7
HNSC	ATP5MC1P6 →	+2.191	+1.432	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,140 associations by consensus.

Exploration

SERPINB5 survival (RNA) · tumor vs normal (RNA) · all SERPINB5 data types