Across TCGA patient cohorts, SERPINB5 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERPINB5-associated genes across cancer lineages are EGFR_pY1068, GATA6, and Heregulin. Each is linked with SERPINB5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERPINB5-to-partner and partner-to-SERPINB5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINB5→partner) and Y-score (partner→SERPINB5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.262	-2.459	.030	.020	3	1
UCEC	GATA6 →	-0.177	-2.314	.022	.035	3	1
UCEC	Heregulin →	-0.119	-2.321	.045	.034	3	1
UCEC	ACVRL1 →	-0.132	-2.980	.045	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.191	-2.999	.018	.035	3	1
UCEC	P-Cadherin →	-0.187	-2.990	.007	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Exploration

SERPINB5 survival (RNA) · tumor vs normal (RNA) · all SERPINB5 data types