Across TCGA pan-cancer cohorts, SERPINB4 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SERPINB4 data layer compared with 24 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SERPINB4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SERPINB4 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, UCEC, and ESCA are the cancer types where SERPINB4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.102	0.768	<.001	48	view →
UCEC	DFS	Median	II,III,IV	0.933	0.428	.008	26	view →
ESCA	OS	Median	All	0.095	0.701	<.001	12	view →
LUSC	OS	Median	II,III,IV	0.279	0.742	.032	6	view →
SKCM	DFS	Median	All	0.438	0.647	.032	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: SERPINB4 tumor-vs-normal RNA expression · all SERPINB4 data types