Across TCGA pan-cancer cohorts, SERPINB4 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SERPINB4 data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SERPINB4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SERPINB4 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

PDAC, LSCC, and LUAD are the cancer types where SERPINB4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	II,III,IV	0.264	0.489	.011	15	view →
LSCC	DFS	Tertile	III,IV	0.867	0.364	.017	9	view →
LUAD	OS	Quartile	III,IV	0.268	0.738	.026	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: SERPINB4 tumor-vs-normal RNA expression · all SERPINB4 data types