Across TCGA patient cohorts, SERPINB4 protein abundance is significantly associated with the RNA expression of many other genes, with 6,988 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible SERPINB4-associated genes across cancer lineages are TCN1, SERPINB7, and SPRR1B. Each is linked with SERPINB4 in more than 4 cancer types. Because this analysis shows association rather than direction, both SERPINB4-to-partner and partner-to-SERPINB4 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINB4→partner) and Y-score (partner→SERPINB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TCN1 →	+2.425	+2.616	<.001	.002	3	4
UCEC	SERPINB7 →	+2.293	+2.482	.008	.006	2	5
LSCC	SPRR1B →	+3.165	+1.685	<.001	<.001	3	4
HNSC	KRT6B →	+3.240	+1.276	<.001	<.001	3	4
LSCC	ID1 →	+1.037	+1.223	<.001	.005	3	4
HNSC	DEFB4A →	+3.525	+1.005	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,988 associations by consensus.

Exploration

SERPINB4 survival (RNA) · tumor vs normal (RNA) · all SERPINB4 data types