Across TCGA patient cohorts, SERPINB4 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERPINB4-associated genes across cancer lineages are MSH2, STAT3_pY705, and CD20. Each is linked with SERPINB4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERPINB4-to-partner and partner-to-SERPINB4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINB4→partner) and Y-score (partner→SERPINB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.179	-1.848	.043	.049	3	2
UCEC	STAT3_pY705 →	-0.574	-3.247	<.001	<.001	3	2
UCEC	CD20 →	+0.149	+2.135	.003	.010	3	2
SKCM	ACC_pS79 →	+0.238	+1.514	.015	.014	3	2
UCEC	eEF2 →	+0.379	+2.584	.005	.010	3	1
UCEC	EGFR_pY1173 →	+0.064	+1.704	.036	.013	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

Exploration

SERPINB4 survival (RNA) · tumor vs normal (RNA) · all SERPINB4 data types