SERPINB3

Across TCGA pan-cancer cohorts, SERPINB3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SERPINB3 data layer compared with 20 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SERPINB3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SERPINB3 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

PDAC, HNSC, and LUAD are the cancer types where SERPINB3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	III,IV	0.680	0.916	.005	28	view →
HNSC	OS	Tertile	All	1.000	0.259	.014	22	view →
LUAD	DFS	Quartile	All	0.385	1.000	.003	14	view →
LSCC	DFS	Tertile	II,III,IV	0.438	1.000	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SERPINB3–PDAC (OS)

Open the PDAC breakdown →