SERPINB3

Across TCGA pan-cancer cohorts, SERPINB3 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of SERPINB3’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where SERPINB3 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types SERPINB3 is over-expressed in tumor, although a few such as HNSC and LUAD show the opposite, repressed pattern.

PDAC, LSCC, and HNSC are the cancer types where SERPINB3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SERPINB3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Male	All	+1.746	<.001	10	view →
LSCC	Female	All	+1.652	<.001	8	view →
HNSC	Male	All	−0.489	.005	5	view →
LUAD	Female	All	−0.767	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

SERPINB3–PDAC

Open the PDAC breakdown →