SERPINB3

Across TCGA patient cohorts, SERPINB3 RNA expression is significantly associated with the protein abundance of many other proteins, with 7,244 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SERPINB3-associated proteins across cancer lineages are S100A8, XPC, and SPRR2D. Each is linked with SERPINB3 in more than 4 cancer types. Because this analysis shows association rather than direction, both SERPINB3-to-partner and partner-to-SERPINB3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SERPINB3 versus S100A8 in BRCA, with a Pearson correlation of 0.36.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINB3→partner) and Y-score (partner→SERPINB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	S100A8 →	+1.777	+0.754	<.001	.001	3	5
BRCA	XPC →	-0.301	-0.666	<.001	.007	3	5
UCEC	SPRR2D →	+3.136	+2.635	.005	.003	3	4
PDAC	SPRR2D_S38 →	+3.167	+4.860	.001	<.001	3	4
BRCA	TRIM29 →	+1.315	+0.621	<.001	.001	3	4
BRCA	TRIM29_S21 →	+1.546	+0.798	<.001	.006	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,244 associations by consensus.

SERPINB3 vs S100A8 — BRCA

Explore this scatter interactively →