SERPINB3

Across TCGA patient cohorts, SERPINB3 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERPINB3-associated genes across cancer lineages are Stathmin, FoxM1, and PCNA. Each is linked with SERPINB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERPINB3-to-partner and partner-to-SERPINB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Stathmin grouped by SERPINB3-low versus SERPINB3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINB3→partner) and Y-score (partner→SERPINB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Stathmin →	+0.118	+2.169	.021	.002	3	2
UCEC	FoxM1 →	+0.248	+1.584	.007	.019	3	2
UCEC	PCNA →	+0.255	+2.502	.001	.001	3	2
UCEC	PKC-b-II_pS660 →	-0.223	-1.925	.025	.005	3	2
SKCM	p90 RSK →	+0.126	+1.415	.038	.037	3	1
SKCM	14-3-3_zeta →	+0.131	+1.000	.028	.039	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Stathmin by SERPINB3 expression — SKCM

Explore this box plot interactively →