SERPINB3

Across TCGA cell cohorts, SERPINB3 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,105 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible SERPINB3-associated GO terms across cancer lineages are Positive regulation of complement activation, Complement activation, alternative pathway, and Zymogen activation. Each is linked with SERPINB3 in more than 5 cancer types. Because this analysis shows association rather than direction, both SERPINB3-to-partner and partner-to-SERPINB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of complement activation grouped by SERPINB3-low versus SERPINB3-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINB3→partner) and Y-score (partner→SERPINB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Positive regulation of complement activation →	+0.941	+0.971	.004	.007	3	6
BREAST	Complement activation, alternative pathway →	+1.303	+1.427	<.001	.007	3	6
UPPER_AERODIGESTIVE_TRACT	Zymogen activation →	+0.219	+3.065	<.001	<.001	3	6
BREAST	Complement-mediated synapse pruning →	+1.504	+1.211	<.001	.005	3	5
BREAST	Vertebrate eye-specific patterning →	+1.409	+1.209	<.001	.005	3	5
BREAST	Keratinocyte migration →	+0.870	+0.904	.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,105 associations by consensus.

Positive regulation of complement activation by SERPINB3 expression — LUNG_NSCLC_LUAD

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