Across TCGA pan-cancer cohorts, SERPINB2 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SERPINB2 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SERPINB2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SERPINB2 expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

PDAC, HNSC, and OV are the cancer types where SERPINB2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	III,IV	0.509	0.205	.010	10	view →
HNSC	DFS	Median	All	0.976	0.909	.040	10	view →
OV	DFS	Median	All	1.000	0.848	.023	4	view →
LUAD	OS	Quartile	All	0.781	0.952	.036	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: SERPINB2 tumor-vs-normal RNA expression · all SERPINB2 data types