Across TCGA patient cohorts, SERPINB2 mutation is significantly associated with the RNA expression of many other genes, with 3,672 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERPINB2-associated genes across cancer lineages are PPP2R5E, GEMIN2, and PDHX. Each is linked with SERPINB2 in more than 3 cancer types. Because this analysis shows association rather than direction, both SERPINB2-to-partner and partner-to-SERPINB2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINB2→partner) and Y-score (partner→SERPINB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PPP2R5E →	+0.526	+2.169	<.001	.003	3	4
UCEC	GEMIN2 →	+0.473	+1.776	.003	.008	3	4
UCEC	PDHX →	+0.566	+2.234	<.001	.001	3	4
UCEC	HNRNPR →	+0.563	+2.202	.003	.001	3	4
UCEC	YARS1 →	+0.533	+2.716	<.001	<.001	3	4
UCEC	DBR1 →	+0.428	+2.262	.004	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,672 associations by consensus.

Exploration

SERPINB2 survival (RNA) · tumor vs normal (RNA) · all SERPINB2 data types