SERPINB12

Across TCGA patient cohorts, SERPINB12 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERPINB12-associated genes across cancer lineages are FASN, p38-MAPK_pT180_Y182, and Annexin-1. Each is linked with SERPINB12 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERPINB12-to-partner and partner-to-SERPINB12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by SERPINB12-low versus SERPINB12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINB12→partner) and Y-score (partner→SERPINB12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.327	+1.906	.039	.016	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.429	-2.000	.017	.030	3	2
UCEC	Annexin-1 →	+0.557	+2.479	.008	.010	3	2
UCEC	Caspase-7-cleavedD198 →	+0.735	+1.874	.002	.049	3	2
UCEC	Cyclin-B1 →	+0.649	+1.906	.004	.016	3	2
SKCM	ACC_pS79 →	+0.394	+3.459	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

FASN by SERPINB12 expression — UCEC

Explore this box plot interactively →