SERPINB10

Across TCGA pan-cancer cohorts, SERPINB10 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SERPINB10 data layer compared with 17 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SERPINB10 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SERPINB10 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

CCRCC, PDAC, and LSCC are the cancer types where SERPINB10 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	1.000	0.856	.003	10	view →
PDAC	DFS	Quartile	II,III,IV	0.695	0.921	.030	8	view →
LSCC	DFS	Tertile	All	0.743	0.333	.035	1	view →
HNSC	DFS	Median	III,IV	0.939	1.000	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SERPINB10–CCRCC (DFS)

Open the CCRCC breakdown →