SERPINB10

Across TCGA patient cohorts, SERPINB10 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERPINB10-associated genes across cancer lineages are ASNS, PKC-b-II_pS660, and Chk2. Each is linked with SERPINB10 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERPINB10-to-partner and partner-to-SERPINB10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by SERPINB10-low versus SERPINB10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINB10→partner) and Y-score (partner→SERPINB10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.504	+3.700	<.001	.001	3	2
SKCM	PKC-b-II_pS660 →	-0.289	-2.321	.048	.035	3	1
SKCM	Chk2 →	-0.221	-2.321	.047	.035	3	1
UCEC	EGFR_pY1068 →	-0.250	-3.000	.015	.001	3	1
UCEC	JNK_pT183_Y185 →	-0.158	-1.794	.023	.027	3	1
UCEC	JNK2 →	+0.294	+3.026	<.001	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

ASNS by SERPINB10 expression — UCEC

Explore this box plot interactively →