SERPINB1

Across TCGA pan-cancer cohorts, SERPINB1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SERPINB1 data layer compared with 29 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher SERPINB1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SERPINB1 expression acts as an unfavorable survival marker.

OV, CESC, and UCEC are the cancer types where SERPINB1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	DFS	Median	All	0.142	0.541	.002	12	view →
CESC	OS	Median	III,IV	0.156	0.657	.027	12	view →
UCEC	OS	Median	IV	0.066	0.755	<.001	12	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SERPINB1–OV (DFS)

Open the OV breakdown →