SERPINB1

Across TCGA pan-cancer cohorts, SERPINB1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SERPINB1 data layer compared with 29 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SERPINB1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SERPINB1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, UCEC, and PDAC are the cancer types where SERPINB1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.858	0.597	<.001	31	view →
UCEC	OS	Median	All	1.000	0.899	.004	18	view →
PDAC	OS	Tertile	IV	0.231	0.973	.024	9	view →
CCRCC	DFS	Quartile	III,IV	1.000	0.672	.010	9	view →
GBM	OS	Tertile	All	0.409	0.737	.003	8	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SERPINB1–HNSC (OS)

Open the HNSC breakdown →