SERPINB1

Across TCGA patient cohorts, SERPINB1 mutation is significantly associated with the RNA expression of many other genes, with 2,408 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERPINB1-associated genes across cancer lineages are MIR578, MIR3173, and NFYBP1. Each is linked with SERPINB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERPINB1-to-partner and partner-to-SERPINB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR578 grouped by SERPINB1-low versus SERPINB1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINB1→partner) and Y-score (partner→SERPINB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MIR578 →	+0.684	+5.069	<.001	.008	3	2
SKCM	MIR3173 →	+0.629	+4.352	<.001	.007	3	2
SKCM	NFYBP1 →	+0.102	+4.352	<.001	.007	3	2
CESC	DEFB105A →	+0.128	+6.164	<.001	<.001	3	1
CESC	DCAF8L2 →	+0.108	+4.276	.003	.008	3	1
CESC	IGHD5-24 →	+1.408	+4.669	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,408 associations by consensus.

MIR578 by SERPINB1 expression — HNSC

Explore this box plot interactively →