SERPINB1

Across TCGA patient cohorts, SERPINB1 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERPINB1-associated genes across cancer lineages are ATM, EGFR_pY1068, and ERK2. Each is linked with SERPINB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERPINB1-to-partner and partner-to-SERPINB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by SERPINB1-low versus SERPINB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINB1→partner) and Y-score (partner→SERPINB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.548	-2.087	.001	.005	3	2
UCEC	EGFR_pY1068 →	-0.214	-2.115	.026	.017	3	1
UCEC	ERK2 →	+0.173	+2.584	.019	.010	3	1
UCEC	GAPDH →	+0.443	+1.874	.031	.049	3	1
UCEC	GATA3 →	+0.162	+1.335	.025	.046	3	1
UCEC	ACC1 →	+0.336	+1.678	.016	.023	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

ATM by SERPINB1 expression — UCEC

Explore this box plot interactively →