SERPINB1

Across TCGA cell cohorts, SERPINB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,551 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SERPINB1-associated GO terms across cancer lineages are Negative regulation of endopeptidase activity, Intestinal absorption, and Digestive system process. Each is linked with SERPINB1 in more than 13 cancer types. Because this analysis shows association rather than direction, both SERPINB1-to-partner and partner-to-SERPINB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of endopeptidase activity grouped by SERPINB1-low versus SERPINB1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINB1→partner) and Y-score (partner→SERPINB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of endopeptidase activity →	+1.409	+2.162	<.001	.003	3	14
BONE	Intestinal absorption →	+0.168	+2.646	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Digestive system process →	+0.215	+1.651	<.001	.001	3	12
STOMACH	Regulation of sodium ion transport →	+0.105	+2.103	.003	.002	3	11
OESOPHAGUS	Positive regulation of sodium ion transport →	+0.219	+2.749	.001	.006	3	10
LUNG_NSCLC_LUSC	Purine ribonucleoside monophosphate biosynthetic process →	-0.132	-3.728	.006	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,551 associations by consensus.

Negative regulation of endopeptidase activity by SERPINB1 expression — LUNG_SCLC

Explore this box plot interactively →