SERPINA9

Across TCGA pan-cancer cohorts, SERPINA9 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SERPINA9 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher SERPINA9 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SERPINA9 expression acts as an unfavorable survival marker.

COAD, MESO, and PRAD are the cancer types where SERPINA9 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.157	0.871	<.001	24	view →
MESO	DFS	Median	III,IV	0.082	0.414	.007	18	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SCLC	OS	Median	II,III,IV	0.152	0.777	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SERPINA9–COAD (OS)

Open the COAD breakdown →