SERPINA9

Across TCGA patient cohorts, SERPINA9 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible SERPINA9-associated genes across cancer lineages are Cyclin-B1, MAPK_pT202_Y204, and Caspase-7-cleavedD198. Each is linked with SERPINA9 in more than 2 cancer types. Because this analysis shows association rather than direction, both SERPINA9-to-partner and partner-to-SERPINA9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by SERPINA9-low versus SERPINA9-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINA9→partner) and Y-score (partner→SERPINA9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Cyclin-B1 →	+0.480	+1.807	.004	.026	3	3
SKCM	MAPK_pT202_Y204 →	-0.467	-3.000	.010	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.595	+3.189	.045	.010	3	2
SKCM	eEF2 →	+0.279	+1.807	.039	.026	3	2
SKCM	Ku80 →	+0.231	+3.000	.041	.034	3	2
SKCM	PDCD4 →	-0.594	-2.584	<.001	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Cyclin-B1 by SERPINA9 expression — SKCM

Explore this box plot interactively →