SERPINA7

Across TCGA pan-cancer cohorts, SERPINA7 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SERPINA7 data layer compared with 16 for mass-spec protein and 9 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher SERPINA7 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SERPINA7 expression acts as an unfavorable survival marker, although some lineages such as SKCM and UCEC show a favorable association.

BLCA, READ, and BRCA are the cancer types where SERPINA7 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	III,IV	0.018	0.684	<.001	48	view →
READ	OS	Median	II,III,IV	0.111	0.919	<.001	39	view →
BRCA	DFS	Median	II,III,IV	0.093	0.942	<.001	32	view →
STAD	OS	Median	II,III,IV	0.537	0.660	.022	7	view →
SKCM	DFS	Median	III,IV	0.625	0.214	.040	5	view →
UCEC	DFS	Median	II,III,IV	0.862	0.435	.043	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SERPINA7–BLCA (OS)

Open the BLCA breakdown →