SERPINA7

Across TCGA pan-cancer cohorts, SERPINA7 mass-spec protein is linked to patient survival in 9 of 34 cancer types, making it a survival-associated SERPINA7 data layer compared with 16 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher SERPINA7 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SERPINA7 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

COAD, CCRCC, and LUAD are the cancer types where SERPINA7 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	II,III,IV	0.861	1.000	.033	36	view →
CCRCC	DFS	Median	III,IV	0.891	0.534	.005	26	view →
LUAD	DFS	Tertile	III,IV	0.214	0.854	.001	24	view →
UCEC	DFS	Quartile	III,IV	0.262	1.000	.013	8	view →
LSCC	DFS	Tertile	II,III,IV	0.832	1.000	.018	7	view →
PDAC	OS	Median	IV	0.836	0.491	.024	5	view →
OV	DFS	Median	All	1.000	0.716	.045	4	view →
HNSC	OS	Tertile	All	0.951	1.000	.032	4	view →
GBM	DFS	Median	All	0.293	0.462	.025	2	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

SERPINA7–COAD (DFS)

Open the COAD breakdown →