SERPINA7

Across TCGA patient cohorts, SERPINA7 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERPINA7-associated genes across cancer lineages are PKC-delta_pS664, AR, and FASN. Each is linked with SERPINA7 in more than 2 cancer types. Because this analysis shows association rather than direction, both SERPINA7-to-partner and partner-to-SERPINA7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-delta_pS664 grouped by SERPINA7-low versus SERPINA7-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINA7→partner) and Y-score (partner→SERPINA7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PKC-delta_pS664 →	-0.173	-2.459	.007	.017	3	3
UCEC	AR →	-0.306	-1.765	.029	.014	3	2
UCEC	FASN →	+0.315	+1.765	.033	.014	3	2
UCEC	Notch1 →	+0.233	+2.713	<.001	.003	3	2
UCEC	PCNA →	+0.345	+3.906	<.001	<.001	2	3
UCEC	ASNS →	+0.430	+1.807	.001	.025	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

PKC-delta_pS664 by SERPINA7 expression — SKCM

Explore this box plot interactively →