SERPINA6

Across TCGA pan-cancer cohorts, SERPINA6 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SERPINA6 data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SERPINA6 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SERPINA6 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

LUAD, COAD, and CCRCC are the cancer types where SERPINA6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	II,III,IV	0.795	1.000	.005	38	view →
COAD	DFS	Median	II,III,IV	0.880	1.000	.020	30	view →
CCRCC	DFS	Median	All	0.862	0.635	.009	25	view →
UCEC	DFS	Quartile	III,IV	0.240	1.000	.021	16	view →
HNSC	OS	Quartile	All	0.911	1.000	.009	12	view →
GBM	OS	Median	All	0.274	0.526	.011	5	view →
LSCC	DFS	Median	All	0.893	0.976	.026	4	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SERPINA6–LUAD (OS)

Open the LUAD breakdown →