SERPINA6

Across TCGA patient cohorts, SERPINA6 mutation is significantly associated with the RNA expression of many other genes, with 952 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERPINA6-associated genes across cancer lineages are NAA35, HMGB3, and E2F2. Each is linked with SERPINA6 in more than 2 cancer types. Because this analysis shows association rather than direction, both SERPINA6-to-partner and partner-to-SERPINA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NAA35 grouped by SERPINA6-low versus SERPINA6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINA6→partner) and Y-score (partner→SERPINA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NAA35 →	+0.495	+2.436	.004	.002	3	3
SKCM	HMGB3 →	+0.537	+2.166	.005	.008	3	3
SKCM	E2F2 →	+0.433	+2.331	.008	.003	3	3
BLCA	RN7SL66P →	+0.257	+5.177	<.001	.007	3	2
BRCA	RNA5SP487 →	+0.283	+8.471	<.001	.005	3	2
LUAD	ZNF473 →	+0.541	+3.357	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 952 associations by consensus.

NAA35 by SERPINA6 expression — UCEC

Explore this box plot interactively →