SERPINA6

Across TCGA patient cohorts, SERPINA6 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERPINA6-associated genes across cancer lineages are INPP4B, PDK1_pS241, and 14-3-3_beta. Each is linked with SERPINA6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERPINA6-to-partner and partner-to-SERPINA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by SERPINA6-low versus SERPINA6-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINA6→partner) and Y-score (partner→SERPINA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	INPP4B →	+0.971	+2.834	<.001	.035	3	1
LUSC	PDK1_pS241 →	+0.189	+2.816	.017	.036	3	1
UCEC	14-3-3_beta →	-0.113	-2.973	.015	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.213	-2.571	.006	.011	3	1
UCEC	JNK2 →	+0.350	+3.700	<.001	.001	3	1
UCEC	Paxillin →	+0.315	+2.820	.008	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

INPP4B by SERPINA6 expression — LUSC

Explore this box plot interactively →