SERPINA6

Across TCGA cell cohorts, SERPINA6 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SERPINA6-associated genes across cancer lineages are UCMA, GYS2, and KRTAP13-4. Each is linked with SERPINA6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERPINA6-to-partner and partner-to-SERPINA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UCMA grouped by SERPINA6-low versus SERPINA6-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINA6→partner) and Y-score (partner→SERPINA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	UCMA →	+0.059	+2.926	<.001	.009	3	1
SKIN	GYS2 →	+0.016	+4.467	<.001	.004	3	1
SKIN	KRTAP13-4 →	+0.030	+5.022	<.001	.002	3	1
SKIN	KRTAP19-8 →	+0.161	+4.415	<.001	.007	3	1
BREAST	GZMK →	+0.056	+5.169	<.001	.005	3	1
LUNG_NSCLC_LUAD	KRTAP22-2 →	+0.221	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

UCMA by SERPINA6 expression — BLOOD_Leukemia

Explore this box plot interactively →