SERPINA12

Across TCGA patient cohorts, SERPINA12 mutation is significantly associated with the RNA expression of many other genes, with 1,797 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERPINA12-associated genes across cancer lineages are CDKN3, CKS2, and CHAC2. Each is linked with SERPINA12 in more than 2 cancer types. Because this analysis shows association rather than direction, both SERPINA12-to-partner and partner-to-SERPINA12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDKN3 grouped by SERPINA12-low versus SERPINA12-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINA12→partner) and Y-score (partner→SERPINA12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CDKN3 →	+0.722	+2.328	<.001	.003	3	3
SKCM	CKS2 →	+0.653	+3.195	.005	.009	3	3
SKCM	CHAC2 →	+0.662	+2.328	.001	.003	3	3
SKCM	SLC20A1 →	+0.885	+3.594	.007	.001	3	3
LUAD	UBE2T →	+1.005	+3.471	.002	.002	3	3
UCEC	UBC →	+0.438	+3.098	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,797 associations by consensus.

CDKN3 by SERPINA12 expression — SKCM

Explore this box plot interactively →