SERPINA12

Across TCGA patient cohorts, SERPINA12 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERPINA12-associated genes across cancer lineages are C-Raf, EGFR_pY1068, and MEK1. Each is linked with SERPINA12 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERPINA12-to-partner and partner-to-SERPINA12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by SERPINA12-low versus SERPINA12-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINA12→partner) and Y-score (partner→SERPINA12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	C-Raf →	+0.158	+3.355	.003	.005	3	2
UCEC	EGFR_pY1068 →	-0.229	-2.115	.036	.019	3	2
UCEC	MEK1 →	+0.362	+2.321	.023	.034	3	1
UCEC	p62 Lck ligand →	+0.366	+3.169	.010	.018	3	1
UCEC	PCNA →	+0.239	+2.115	.011	.019	2	2
UCEC	ATM →	-0.652	-2.115	<.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

C-Raf by SERPINA12 expression — LUAD

Explore this box plot interactively →